On 20 April 2005, Moreno made her first bout with Clara Pérez in Mexico City, winning on a unanimous decision and celebrating her debut match with a white star.
On 30 November in Karlsruhe, Germany, she fought against GBU women's super flyweight champion Alesia Graf in her first overseas match, losing by UD in 10 rounds.
On 29 November, she faced WBC women's international flyweight champion Mariana Juárez at Arena México in Mexico City, losing by UD.
On 13 February 2010, Moreno fought Carolina Montenegro for WBC Youth Female Light Flyweight Championship bout, which was held in Ciudad Nezahualcóyotl, winning in round four via KO.
On 15 May, she fought against Abigail Villar in Chicoloapan, Mexico, winning in the sixth round via TKO and successfully defending the youth female light flyweight title for the first time.
Moreno then fought Jessica Chávez for the Mexican interim, and WBC Silver female light flyweight titles on 19 February 2011 at the Deportivo Trabajadores del Metro in Iztacalco, Mexico.