Esperstedt is a village and a former municipality in the Saalekreis district, Saxony-Anhalt, Germany.

[1] Esperstedt is situated on the river Weida and is located between Halle (Saale) and Querfurt.

The earliest known documented mention of the village is listed in Hersfeld Abbey's tithing rolls from between 881 and 899 as the tithable place Osperstadt in Friesenfeld.

The name is derived from the word Espen meaning aspen or poplar tree.

Exit 20 of the Bundesautobahn 38 Göttingen–Leipzig is located at the edge of town.