Espy Run is a tributary of Nanticoke Creek in Luzerne County, Pennsylvania, in the United States.

It is approximately 2.4 miles (3.9 km) long and flows through Nanticoke and Hanover Township.

[1] Espy Run joins Nanticoke Creek 0.42 miles (0.68 km) upstream of its mouth.

The instantaneous discharge of the stream at the gage at Nanticoke was measured to be 2.0 cubic feet per second in June 1999 and 2.9 in October 1999.

[3] In June 1999, the concentration of dissolved oxygen in Espy Run at Nanticoke was measured to be 9.6 milligrams per liter.

[3] In June 1999, the concentration of dissolved aluminum in Espy Run at the Nanticoke stream gage was less than 10.0 micrograms per liter.

[1] Espy Run is at the southwestern end of the Northern Middle Anthracite Field.

[3] In the lower reaches of Espy Run, the surficial geology mainly consists of coal dumps, urban land, and Wisconsinan Till.

[6] Espy Run was entered into the Geographic Names Information System on August 2, 1979.

[7] A passive treatment system has been built on an unnamed mine seep discharging into Espy Run.