The first stage of the stadium opened in 1999 and was used by Lobos de la BUAP, a professional football club that plays in the Ascenso MX.

In 2017, Lobos were promoted to Liga MX, and as the venue seats more than the 20,000 minimum for a first-division football stadium, no expansion was necessary, even though the Estadio Universitario BUAP is the smallest stadium in the league.

[1] Prior to Lobos' promotion to Liga MX, some top-flight teams had used the stadium due to special events and renovations.

Veracruz played the final two home games of the Apertura 2014 tournament in the Estadio Universitario BUAP, as the Estadio Luis "Pirata" Fuente was being used to host the 2014 Central American and Caribbean Games.

In 2020, Artilleros de Puebla from the Liga de Fútbol Americano Profesional, the top American football league in Mexico, moved to the stadium.