Estelle Denis was born in Paris but spent her childhood in Le Coudray-Montceaux, a town in the department of Essonne.

In 2002, she started presenting the first direct programs of the Ligue 1 commented by Jean-Philippe Goron and Raymond Domenech who were then replaced by Christophe Josse and Jean-Luc Arribart in 2004.

She hosted with the same team 100% Coupe du monde, a talk-show about the events during the 2006 Football World Cup in Germany.

In 2006, she hosted Le Tournoi des as on Paris Première, a poker tournament that opposed celebrities and professionals of the game.

Denis was previously married to French footballer and manager Raymond Domenech, whom she met at the studios of channel Infosport+.