Eucalyptus megasepala is a species of medium-sized tree that is endemic to Far North Queensland and Cape York Peninsula.

Eucalyptus megasepala is a tree that typically grows to a height of 10–20 m (33–66 ft) and forms a lignotuber.

[2][3] Eucalyptus megasepala was first formally described in 2006 by Anthony Bean and the description was published in the journal Austrobaileya from a specimen collected near Jowalbinna (near Laura).

[5][6] This eucalypt grows in open woodland on sandstone hills between the Iron Range on Cape York to Irvinebank and Mount Mulgrave in Far North Queensland.

[2][3] This eucalypt is classified as "least concern" under the Queensland Government Nature Conservation Act 1992.