The Euclid Avenue Historic District is a historic district in downtown Cleveland, Ohio, United States.

Established and listed on the National Register of Historic Places in 2002, it comprises 125 acres (51 ha) along Euclid Avenue and parallel streets from Public Square to East 21st Street.

In 2007, another 4 acres (1.6 ha) was added to the district; the boundary increase included buildings exclusively located along parallel streets.

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