Her modeling career took off when she appeared on the cover of Glamour, and walked the runway for multiple designers including Yves Saint Laurent, Alexander McQueen, Thierry Mugler.

She starred in national commercials for RC Cola, M&Ms, October chocolate and Russian TV shows like Pole Chudes and Yeralash before being approached by a talent scout from Paris.

[3] She has also been featured in magazines, such as Elle, Harper's Bazaar, Marie Claire, Japanese and Russian Vogue, GQ, Self, Shape, As well as catalogs for Hermès and Cartier.

In 2019, Kuzmina appeared in Todd Strauss-Schulson's film Isn't It Romantic, alongside Rebel Wilson, and The Gentlemen opposite Michelle Dockery.

in 2022, Kuzmina created a Stand Up Show," Models of Comedy," which stars a cast of top models doing Comedy Eugenia Kuzmina resides in Los Angeles with her film producer husband Bill Block, who has been CEO of Miramax since April 2017 and two children.