She wrote extensively for the North American Review, the Christian Examiner, the Boston Evening Transcript, and other well-known publications.

[3] Her father was well-known as an author, publisher, inventor, public lecturer and a professor of astronomy and other branches of mathematics, making a specialty of navigation; he died in Brooklyn in 1866.

She also edited a weekly literary paper the Saturday Evening Union, and supplied leading articles for the Watch Tower.

At that time, she was also writing for the North American Review and Christian Examiner, all the editorials for the Bay State, a weekly published in Lynn, with occasional articles in the Boston daily journals, the Transcript, Traveller, Atlas, and others.

In 1854, she wrote and published the history of the town of Newburyport, and a scientific work on the use of ether and chloroform applied to practical dentistry.

To settle a wager between two friends, one of whom bet that no one "could impose on the New York Herald," and the other thinking it might be possible, Blake wrote a "Great Manifesto!

[7] In 1863, she married, in New York, Dr. Daniel S. Blake,[5] who had been for ten or fifteen years a surgeon dentist in Newburyport.

She wrote several lectures on historical and social topics for a literary bureau in New York, which were repeatedly delivered by a man who claimed them as his own.

[3] Euphemia Vale Blake died 21 October 1904 at her home in Brooklyn,[3] and is buried in that city's Green-Wood Cemetery.