[5] When the school was founded it was located on the premises of a former furniture shop in the Limpertsberg quarter of Luxembourg city.

In 2014 the Luxembourgish government signed an agreement for the European Schools to accept 100 more students in their English and French sections.

[4] Due to their few numbers the students studied their mother tongue under special arrangements, and they shared many other classes such as Philosophy, Geography, History, and Human Science within the sections of their second language, which could be either in English, French, or German.

Some foreign students were also admitted in very rare cases, from countries that were not in the European Union at that time, but whose parents were working in Luxembourg.

The DNA which is made up of four simple building blocks called nucleotides, identified by the letters A, T, C, and G, was made with the help of pupils from both primary and secondary school cycles who stepped out in the courtyard, forming two rows facing the opposite direction and extending their right arms towards each other, wearing colored paper cuffs on their forearms, which represented the four letters of the building blocks of the DNA; their left arms resting on the shoulders of the pupils in front of them.

[10] In the mid 2000s, a false bomb alert caused the closure of the school's premises in the early mornings before the start of the classes.

Teachers from the school collaborated with the police in the first hour of their arrival to identify the perpetrator via a recording of his phone call.

Shortly before his scheduled class, he used a payphone located in downtown Luxembourg to contact the school's administrative office.

When the school failed to close immediately in response to his call, he proceeded to contact a local police department to initiate the alarm.