European route E25 is a north–south European route from Hook of Holland in the Netherlands, to Palermo in Italy which includes ferry crossings from Genoa to Bastia (Corsica), from Bonifacio to Porto Torres (Sardinia) and from Cagliari to Palermo (Sicily).

It passes through the following cities: Hook of Holland – Rotterdam – Utrecht - Eindhoven – Maastricht – Liège – Bastogne – Arlon – Luxembourg City – Metz – Saint-Avold – Strasbourg – Mulhouse – Basel – Olten – Bern – Lausanne – Geneva – Mont Blanc Tunnel – Aosta – Ivrea – Vercelli – Alessandria – Genoa ... Bastia – Porto-Vecchio – Bonifacio ... Porto Torres – Sassari – Cagliari ...

The Belgian 'Route du Soleil' is a branch of the original route, connecting Amsterdam and Marseille and joining the E25 near Utrecht (NL) towards Metz (F).

On 14 August 2018 a section of the A10 motorway called the Morandi Bridge collapsed in the city of Genoa, Italy, claiming the lives of 43 civilians.

The reason for the collapse was a mix between what a witness reports as a lightning strike and poor design and questionable construction methods.