[1] While a student, he worked as a paid intern for a biomedical company, as a careers instructor in Cape Town, South Africa, and at Intuit on the TxtWeb project.

[7] Later that year, Spiegel worked with fellow Stanford classmates Bobby Murphy and Reggie Brown to launch a prototype of this concept called "Picaboo", which they later renamed as Snapchat.

[11][12] In February 2017, Spiegel and Murphy pledged to donate upwards of 13,000,000 shares of Class A common stock over the next 15–20 years to an arts, education and youth non-profit.

[15][13][14] In January 2017 The Wall Street Journal reported that after the predicted March 2017 initial public offering for Snap Inc., Murphy and Evan Spiegel would hold over "70% of the voting power" in the company, and own around 45% of the total stock.

[22] Just a month before Spiegel's engagement to Kerr, he purchased a 7,164 square foot, $12 million house that was previously owned by Harrison Ford.

[35] In 2022, at the Otis College of Art and Design commencement, Spiegel announced that he and Miranda Kerr would pay off the 2022 graduating class student's debt.

The emails included misogynistic and homophobic comments and openly encouraged getting women heavily drunk in an attempt to convince them to have sex.

[37][38][39][40] Spiegel issued a statement responding to the controversy stating, "I'm obviously mortified and embarrassed that my idiotic emails during my fraternity days were made public.