In late 2021, a planned merger with Edward-Elmhurst Health was announced, pending regulatory approval, for a potential system total of nine hospitals.

Glenbrook offers cardiac catheterization and ultra fast CT scan, total hip and knee replacement, the Eye and Vision Center for LASIK and other eye surgery, and neurological services including a new sleep center, a cognitive and memory disorder program and a Parkinson's Disease clinic.

[citation needed] The hospital has a Level II trauma center and Fast Track service for patients with minor illnesses and injuries.

HPH's Kellogg Cancer Center has facilities to offer care to oncology patients in Lake County.

The hospital offers care for the following types of cancer: thoracic and lung; hematology; breast; ovarian; head and neck; melanoma and sarcoma; gastrointestinal; prostate; and stomach.

[citation needed] Skokie Hospital, formerly Rush North Shore Medical Center, joined NorthShore University HealthSystem in January 2009.

Emphasis is on translational and clinical research allowing discoveries from the basic sciences and engineering to be brought promptly to the bedside.

[6] In 2021, Northshore University HealthSystem was sued by employees who were denied a religious exemption from taking the COVID-19 injection and fired from their jobs.

As part of the settlement awarded in the federal Northern District Court of Illinois, Northshore was ordered to rehire the workers and pay them a total of $10.3 million in damages.

[7] The dozen plus dismissed employees from Northshore were joined by other fired healthcare workers for a class-action suit on behalf of 500 individuals, each of whom was awarded $25,000 plus additional monetary damages if they later complied and took the vaccine.

While this was not the first legal decision protecting workers from being permanently fired for refusing the shot, it did set precedent as the first case in the U.S. in which petitioners were awarded monetary damages for abrogation of their Title VII rights.