Chiao and Sharipov docked at the Space Station on 16 October 2004 aboard Soyuz TMA-5, to relieve Expedition 9 crewmates Mike Fincke and Gennady Padalka.

Notable accomplishments included replacing critical hardware in the Quest Joint Airlock; repairing U.S. spacesuits; and submitting a scientific research paper on ultrasound use in space.

European Space Agency Astronaut Roberto Vittori of Italy launched to the Station with the Expedition 11 crew and spent eight days onboard performing scientific experiments.

The re-entry of the Soyuz TMA-5 spacecraft was perfect, returning the astronauts to Earth 53 miles northeast of the town of Arkalyk after 192 days, 19 hours and 2 minutes in space.

The Expedition 10 crew completed two spacewalks, including experiment installation and tasks to prepare the Station for the arrival of the new European Automated Transfer Vehicle in 2006.