The crew arrived and departed aboard Soyuz TMA-6, which stayed at the station for the duration of the expedition in case it was needed for emergency evacuation.

Expedition 11 commander Sergey Krikalev and flight engineer John Phillips arrived at the International Space Station aboard Soyuz TMA-6 on 17 April 2005 at 02:19 UTC.

After a one-week handover period, Expedition 10 commander Salizhan Sharipov and flight engineer Leroy Chiao departed aboard Soyuz TMA-5, along with Vittori on 24 April 2005 18:44 UTC.

[6] During the Expedition 11 mission, Krikalev exceeded the record for total time in space (formerly held by Sergei Avdeyev with 747.593 days).

They removed and brought inside the station a Russian Biorisk experiment container housing bacteria from the outside of Pirs; an MPAC (a micrometeoroid and orbital debris collector) and SEED (a materials exposure array) panel from the Zvezda Service Module; and the Matroska experiment, (radiation dosimeters in human-tissue-equivalent material).