The expedition began with the departure of Soyuz MS-23 on 27 September 2023[2][3][4] with Danish astronaut Andreas Mogensen taking over the ISS command.

[5] Initially, the expedition consisted of Andreas and his three SpaceX Crew-7 crewmates, Jasmin Moghbeli, Satoshi Furukawa, and Konstantin Borisov from America, Japan, and Russia respectively, as well as Russian cosmonauts Oleg Kononenko (who later assumed the ISS command) and Nikolai Chub (both on a year long ISS mission), and another American astronaut Loral O'Hara, who launched aboard Soyuz MS-24 on September 15, 2023 and were transferred from Expedition 69 alongside the SpaceX Crew-7 astronauts.

[7][8] The crew was later replenished by subsequent crew rotation missions in the expedition, SpaceX Crew-8, consisting of American astronauts Matthew Dominick, Michael Barratt, Jeanette Epps, and Russian cosmonaut Alexander Grebenkin, and Soyuz MS-25, consisting of Russian cosmonaut Oleg Novitsky, Belarusian space tourist Marina Vasilevskaya, and American astronaut Tracy Caldwell-Dyson.

Previous mission: Expedition 69 27 September 2023 – Soyuz MS-23 Undocking, official switch from Expedition 69 9 October 2023 – Nauka outfitting RtoD Add-on Heat Radiator Leak Event 25/26 October 2023 – EVA 1 (VKD-61) Kononenko/Chub: 7 hrs, 41 mins[10] 1 November 2023 – EVA 2 (US-89) Moghbeli/O'Hara: 6 hrs, 42 mins[11] 11 November 2023 – CRS SpX-29 Docking 29 November 2023 – Progress MS-23/84P Undocking 3 December 2023 – Progress MS-25/86P Docking 21 December 2023 – CRS SpX-29 Undocking 22 December 2023 – CRS NG-19 Unberthing & Release 20 January 2024 – Axiom Mission 3 Docking (Non-Expedition crew) 1 February 2024 – CRS Cygnus NG-20 Capture & Berthing 7 February 2024 – Axiom Mission 3 Undocking (Non-Expedition crew) 13 February 2024 – Progress MS-24/85P Undocking 17 February 2024 – Progress MS-26/87P Docking[12] 5 March 2024 – SpaceX Crew-8 Docking[13] 10 March 2024 – ISS Expedition 70 Change of Command Ceremony from Andreas Mogensen to Oleg Kononenko 11 March 2024 – SpaceX Crew-7 Undocking 23 March 2024 – CRS SpX-30 Docking 25 March 2024 – Soyuz MS-25 Docking (Expedition 70/71 & ISS EP-21) 29 March 2024 – Kononenko and Chub's seat liner from Soyuz MS-24 swapped with Novitsky and Vasilevskaya's seat liner from Soyuz MS-25 for MS-24 landing[14] 6 April 2024 – Soyuz MS-24 Undocking, official switch to Expedition 71 Next: Expedition 71 Besides the expedition crew, Crew Dragon visited the station, carrying Axiom Mission 3, consisting of Michael López-Alegría of Axiom Space (formerly NASA), Walter Villadei of the Italian Ministry of Defence, Alper Gezeravcı of the Turkish Space Agency, and Marcus Wandt of the Swedish National Space Agency.

[17] The Soyuz MS-25 vehicle carried expedition member Tracy Caldwell-Dyson and visitors Oleg Novitsky of Roscosmos and Marina Vasilevskaya, a flight attendant trained by the Belarus Space Agency for ISS EP-21.