The expedition began with the departure of Soyuz MS-25 on 23 September 2024 and is led by Sunita Williams, her second time serving as commander of the ISS.

[1] It will continue the extensive scientific research conducted aboard the ISS, focusing on various fields, including biology, human physiology, physics, and materials science.

The expedition consists of Roscosmos cosmonauts Aleksey Ovchinin, Ivan Vagner, and Aleksandr Gorbunov, and NASA astronauts Barry E. Wilmore, Sunita Williams, Donald Pettit, and Nick Hague.

Wilmore and Williams arrived at the station on 6 June 2024 for what was expected to be a brief visit as part of the Boeing Crew Flight Test mission.

[6] Roscosmos cosmonauts Sergey Ryzhikov and Alexey Zubritsky, along with NASA astronaut Jonny Kim, are expected to arrive at the station aboard Soyuz MS-27 in March 2025.