According to the Journal Citation Reports, its 2020 impact factor is 2.969 [1] It covers all areas of physiology, especially work that deals with both physiological and pathophysiological questions that investigate gene/protein function using molecular, cellular, and whole-animal approaches.

All articles become freely accessible 12 months after publication.

The journal publishes themed special issues.

An annual prize is awarded to an early-career scientist who authors the best eligible paper in the journal.

[2] Previous editors in chief, or Chairman of the Editorial Board, include: