The GPe is predominantly composed of inhibitory GABAergic neurons that project axons to the subthalamic nucleus (in the diencephalon), the striatum, internal globus pallidus (GPi) and substantia nigra pars reticulata.

[2] When movement adjustment is required, striatal inhibitory GABAergic axons are sent to the GPe, decreasing inhibition of the subthalamic nucleus.

This multisynaptic indirect striatopallidal pathway allows for regulated excitatory input from the subthalamic nucleus to the GPi and substantia nigra pars reticulata.

This combines with direct pathway inhibition in the GPi, allowing for fine tuned basal ganglia output, and more controlled movement.

Lateral globus pallidus dysfunction has been observed in the following conditions: 2° (Spinomesencephalic tract → Superior colliculus of Midbrain tectum)