Sayer was the eldest son of George Sayer of Doctors' Commons and his wife Mary Exton, daughter of Everard Exton, proctor of Doctors' Commons.
[3] Sayer was returned as Member of Parliament for Helston, as a ministerial nominee, at a by-election on 13 May 1726 and quickly became one of the leading government spokesmen.
On 26 February 1730 he led for the Government against an opposition sponsored petition to end the monopoly of the East India Company.
[3] Sayer died without issue from a riding accident on 24 September 1731[3] and was buried in Durham Cathedral.
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