Ezequiel Franklin Astacio (born November 4, 1979) is a former Major League Baseball pitcher.

On November 3, 2003, Astacio was traded to the Houston Astros along with Taylor Buchholz and Brandon Duckworth in exchange for Billy Wagner.

Typical of a lot of younger pitchers with a plus fastball, he also gave up an eye opening 25 home runs.

He gave up the game-winning home run to Geoff Blum in Game 3 of the 2005 World Series against the Chicago White Sox.

Astacio was claimed off of waivers by the Texas Rangers on March 26, 2007,[1] but he failed to make the team following spring training.