In 2003, he was dealt with Ezequiel Astacio and Brandon Duckworth to the Astros for all-star closer and future Baseball Hall of Fame member Billy Wagner.

Originally forgotten by many fans due to Astacio and Duckworth both quickly being brought up to the majors, Buchholz proceeded to impress scouts in the minors, showing promise for the future.

The first hit came when second baseman Eric Bruntlett double-clutched the ball before throwing, allowing runner Chris Duffy to reach first base safely.

After Jack Wilson singled, Astros manager Phil Garner pulled Buchholz and brought in closer Brad Lidge, who struck out Jason Bay to end the game.

According to SI.com, Buchholz was included as part of a proposed December 7, 2006 trade with the Chicago White Sox to bring Jon Garland to the Astros.

After missing all of 2009 due to Tommy John surgery, Buchholz made his 2010 debut on July 24, giving up a two-run homer to Raúl Ibañez.