FC Nistru Otaci was a Moldovan football club based in Otaci, Moldova.

[1] During the 1999–2000 season, the club played as FC Nistru-Unisport Otaci due to Nistru being expelled in the summer of 1999.

The club merged with Unisport Chişinău, which allowed Nistru to use Unisport's top flight position to play.

However, this merger was canceled in 2000, sending Unisport back down to the Divizia A.

In June 2020, club president Vasile Traghira died.