E.403 is a class of electric locomotives to be used on fast freight trains by the Italian railway company FS Trenitalia.

In the early 2000s Trenitalia developed plans to expand its freight operations into mainland Europe, especially on the Italy-Austria-Germany corridor.

The (limited) Austrian and German approval was given in 2006, with TXLogistik drivers operating the trains in Austria and Germany.

The E.402C programme was renamed E.403 in 2005, with its characteristics finalised in the same year: the locomotive would now be used on fast freight trains, partly operating on the new high-speed lines.

However, by February 2010 no freight train has ever run on HS lines, and the E.403 are not yet entered in regular service.