In 2006, the channel was renamed xL the ViRUS and became affiliated with additional radio shows and podcasts, including Ron and Fez.

The two had been out of work since their firing in August 2002 from WNEW-FM in New York City, after station owner Infinity Broadcasting paid them to stay off the air.

[2] The name High Voltage was decided by one of XM's lawyers without consulting either host, despite them telling Hughes and Cumia they could think of a name.

[2] Opie and Anthony launched on October 4, 2004, and aired weekdays from 6:00 a.m. to around 10:00 a.m. EST, with replays broadcast throughout the day.

[2] In late December 2004 through January 3, 2005, WAQX-FM in Syracuse, New York, aired a censored version of the previous day's show, while The Howard Stern Show was on its Christmas vacation, the first time the pair was heard on terrestrial radio since their firing at WNEW.

[4] On March 14, 2005, the show moved their start and end time back an hour, airing from 7:00 a.m. to 11:00 a.m. each weekday.

[5] In March 2005, the show held "auditions" for other radio personalities to showcase their programs for the possible addition to the High Voltage line-up.

However, shortly after Opie and Anthony returned to FM radio, DirecTV decided to remove the channel from their service, claiming they wanted to go "all music."

In addition, some extra spots on the weekend were dedicated to new weekly shows, such as the Razzle Dazzle Variety Hour, and the Saturday Night Virus.

In May 2007, an Opie and Anthony audio byte appeared on the website Breitbart.tv, which had a clip of their show featuring a homeless man talking about how he would sexually abuse Condoleezza Rice, and the Queen of the United Kingdom.

This clip soon made its way to the Drudge Report, and gained a lot of attention through news media outlets, as this was following the firings of CBS Radio peers Don Imus, and JV & Elvis.

[17] In April 2018, Nick Di Paolo was fired from Sirius XM due to a Tweet that management deemed offensive.

In late 2020, it was announced The Bonfire with Big Jay Oakerson and Dan Soder would fill the 5:00 pm-7:00 pm time slot.

In August 2022, former Volume hosts Eddie Trunk, Nick Carter, Lori Majewski, and Alan Light had their shows moved to different time slots and reformatted to Faction Talk.