Fadrique de Portugal (c. 1465 – 15 January 1539) was a Portuguese politician and cleric.
He was a patrilineal great-grandson of Afonso I, Duke of Braganza, an illegitimate son of King John I of Portugal, as well as a descendant of King Henry II of Castile and Ferdinand I of Portugal.
He had a close relationship with Queen Isabella I of Castile and was with her in her final hours, signing her last will and testament as a witness.
Due to his commitment to the royal family, the Archbishop strongly supported Isabella and Ferdinand's daughter Joanna upon her accession to her parents' thrones and also supported the accession of her son, Charles I, as her co-ruler.
He died in Barcelona on 15 January 1539 and was transferred to the Cathedral of Santa Maria de Sigüenza, where he was buried in the mausoleum that bears his name.