The hotel has 531 rooms, 8 restaurants, and 25 floors and is located alongside the Nile River.

The building is 105 meters high and was designed by architectural firm, Hirsch Bedner Associates.

It also joined The Canadian Embassy and the Children's Cancer Hospital in Egypt to host the Terry Fox Run in 2010.

The Fairmont Nile City has been location for various movie and TV shoots including Gabel El Halal, Baba, Relam, and more.

Some of the hotel's famous guests include Lucy Liu, Samuel L. Jackson, and Salma Hayek.