Chen's breakthrough came in 2008, when her notable work was for the character of Gam Wing Hing (a mute girl) in TVB series Moonlight Resonance, an indirect sequel to Heart of Greed, as she had to learn sign language for the role.

In 2010, Chen was cast in TVB's grand production series No Regrets as second female lead, securing her position as one of Hong Kong's celebrated new actresses, alongside Tavia Yeung, Linda Chung, Myolie Wu, and Kate Tsui.

Queens of Diamonds and Hearts (2012) allowed Chen to experiment with looking 'ugly' on screen as her character Chung Mo Yim, based on historical figure Zhongli Chun, was born with a prominent birth mark on her face.

Chen also starred in 2013's Will Power alongside veteran actors Wayne Lai and Moses Chan where she played the role of Sam Yuet Kan, a junior barrister with a tough personality.

Chen took to the movie scene again in 2011, acting in the first installment of the heartwarming I Love Hong Kong film series, directed and produced by Eric Tsang.

She too worked together with Eric Tsang again who produced and acted in The Fortune Buddies, another Hong Kong comedy film which also co-stars Louis Yuen, Wong Cho-lam and Johnson Lee who are better known as "Fuk Luk Sau" (福祿壽).

Chen's story revolves around pillow demons, where her character Chow Jing Ee is seen to suffer from serious insomnia after her break-up with her boyfriend Yuen Hao Hong, played by Gordon Lam.

The media had focused on the scene where Chen's character accidentally killed her boyfriend and tried to get rid of the corpse by taking off all of his garments and putting him into a vacuum bag.

[10] Chen starred in the Cantonese version of Despicable Me 3 as the voice of Lucy Wilde, an Anti-Villain League agent, Gru's wife and the girls' adoptive mother.

[14] Ever since Chen's contract with Television Broadcasts Limited (TVB) concluded in 2013, she went on to pursue a 4-year Master of Fine Arts in Drama (MFA) Program at Juilliard School with the passion and determination to better herself as a professional artiste.

The MFA Program only accepts 8 to 10 students each year, and encompasses areas such as production, directing, playwriting, pedagogy, and current trends in American and World Theater.

Starring alongside Dayo Wong and Terrance Lau, Skylight was a sold-out show within a few hours, and it received plenty of raving positive reviews including praises for Chen's performance as a theatre actor.

Starting in 2009, Chen has been sporadically participating in the music scene, singing theme songs for The Stew of Life, Links to Temptation, and Queens of Diamonds and Hearts.

In 2011, she brought Sit to attend a church sermon delivered by friend and No Regrets costar Sheren Tang, hoping to expose him to the Christian faith.