Some of the roles she is best known for include Wan Wan in Twin Of Brothers (2004); Eva in Forensic Heroes III (2011); Ting Ting in Gloves Come Off (2012); Coco in Triumph in the Skies II (2013); Gin in Ghost Of Relativity (2015); Tiu Lan in A Fist Within Four Walls (2016); To Man in Mission Run (2022); Sarah in Narcotic Heroes (2023); Seventh Master in No Return (2024) Wu was born and raised in the Central and Western District of Hong Kong.

[8] The initial stage of Wu's acting career was marked by cameos and minor character roles in numerous TV shows often cast as a villain, either a temptress, a mistress, or a concubine.

Wu gained more recognition in 2008 where she won the Most Improved Female Artiste award at the TVB Anniversary Awards for her performances in D.I.E., The Silver Chamber of Sorrows, the Wars of In-Laws II, and Legend of the Demigods; and additionally nominated for Best Supporting Actress for her portrayal of Ha Fei Fei in The Silver Chamber of Sorrows.

From 2009 to 2011, Wu was cast in major supporting roles in a number of popular and memorable dramas including Rosy Business, No Regrets, Gun Metal Grey, Forensic Heroes III, and D.I.E.

Forensic Heroes III marked the first time Nancy was cast in a more serious, intellectual role as Eva Chow, a capable barrister best remembered by the audience for her ambition and arrogance.

She performed in the 2018 staging of By Chance: Xu Zhimo with Steven Ma where she sung Kunqu opera and danced with 3-meter length water sleeves.

She participated in the 2018 Ronald McDonald House Charities Hong Kong Open Day event, and promoted the organization's fundraiser in 2019.

[25][26][27] Wu, along with William So, and Kimbee Chan participated in the 125th Anniversary celebration launch of Ebenezer School & Home for the Visually Impaired in 2021.

[29] In 2024, Wu visited Ethiopia as a Plan International ambassador, and narrated a Female genital mutilation awareness video for the organization.

They formed the sisterhood group “胡說八道會” after the Chinese idiom “胡說八道”, meaning "nonsense talk", in addition to several members sharing the same last name, Wu “胡”.