She then made two voyages to Africa as a slave ship in the triangular trade in enslaved people.

Fame entered Lloyd's Register in 1779 with J. Burrows, master, and trade Bristol transport.

[5] Captain Henry Liddell sailed from Portsmouth on 31 July 1796, bound for Madras and Calcutta.

1st enslaving voyage (1799-1800): Captain Diedrick Woolbert sailed from London on 27 November 1799.

Lloyd's List (LL) reported on 27 December that Fame, Woolbert, master, had put into Sheerness, having lost anchors and cables.