Fame entered Lloyd's Register in 1819 with C. Jordain, master, changing to Remmington, and trade London—India.

Homeward bound, she was at Diamond Harbour on 12 February 1820, reached St Helena on 7 May, and arrived at Blackwall on 10 July.

On 2 February 1824, Fame caught fire about 50 miles southwest of Bencoolen in the evening after she had left there for England.

A fire started when a careless steward carrying a candle accidentally ignited fumes while drawing brandy from a cask in a storeroom.

[8] In the aftermath of the fire Captain Young, his passengers, including Sir Stamford and Lady Raffles and their children, and Fame's crew shipped aboard Mariner for the voyage to England.