63901107373ENSG00000166801ENSMUSG00000024691Q96PZ2Q9D2L9NM_001312910NM_001312911NM_022074NM_001369455NM_001369456NM_001369457NM_026640NM_001346545NP_001299840NP_071357NP_942144NP_001356386NP_001361733NP_001361777NP_001361778NP_001361779NP_001361780NP_001361781NP_001361782NP_001361783NP_001361784NP_001361785NP_001361786NP_001361787NP_001361788NP_001361789NP_001361790NP_001361791NP_001361792NP_001361793NP_001361794NP_001361795NP_001361796NP_001361797NP_001361798NP_001361799NP_001333474NP_080916Family with sequence similarity 111 member A is a protein that in humans is encoded by the FAM111A gene.

[5] The protein encoded by this gene is cell-cycle regulated, and has nuclear localization.

The C-terminal half of the protein shares homology with trypsin-like peptidases and it contains a PCNA-interacting peptide (PIP) box that is necessary for its co-localization with proliferating cell nuclear antigen (PCNA).

Monoallelic variants in this gene have been associated with dominantly inherited Kenny-Caffey syndrome (KCS; MIM 127000[6]) and the more severe osteocraniostenosis (OCS; MIM 602361[7]), both characterized by short stature, hypoparathyroidism, bone development abnormalities, and hypocalcemia.

You can help Wikipedia by expanding it.This article incorporates text from the United States National Library of Medicine, which is in the public domain.