The highway is approximately 11.4 miles (18.3 km) in length, and travels from FM 64 in the community of Antioch to SH 154 in the county seat of Cooper.

The route of the highway has been altered since its designation, including rerouting due to the construction of Cooper Lake.

The roadway proceeds east, intersecting several county roads and traveling past several small houses.

The roadway passes several small buildings in the community before reaching its eastern terminus, an intersection with SH 154 and State Highway 24 Business.

[5] and on September 28, 1949, through the order of the Texas Transportation Board, FM 1528 was designated, and Spur 39 was redesignated as part of the highway.