Moving to Milan the following year, he enrolled in the Reale Istituto Tecnico Superiore and then continued his studies at the Politecnico di Milano at the School of Applied Industrial Engineering.
After this, Melotti enrolled at the Accademia di Brera in Milan, working alongside Lucio Fontana under the tutelage of sculptor Adolfo Wildt.
[8] At this time, Melotti created his most iconic series, a set of purely abstract sculptures, which he exhibited at the progressive Milanese abstractionist gallery Il Milione, in 1935.
[10] In 1938, Melotti received his first major Fascist commission to create maquettes sculpture for the E 42 (Esposizione universale di Roma 1942 or Universal Exposition of 1942) project.
Through the 1970s and '80s, his work was much acclaimed and he won a number of national and international prizes for sculpture, culminating in a major retrospective at the Forte Belvedere in Florence in 1981.