While the seminary operated only from 1839 to 1862, its legacy is often linked to the decision to establish the University of Arkansas in Fayetteville.
[5] In 1839, Fayetteville Female Seminary welcomed its first class of students, which included 14 girls from prominent Cherokee families.
[6] According to myth, a thespian society met on the first floor, and Sawyer diligently watched over her students to protect them from "any adverse influence or potential moral degradation stemming from the less strict ethical standards associated with actors".
Due to the school's success, Judge David Walker provided Sawyer land upon which to build a permanent structure.
[6] Sawyer maintained her connection with the American Board of Missions, though the school operated independently.