Federal Agents vs. Underworld, Inc. (1949) is a 12-episode black-and-white film serial produced by Republic Pictures during July 1948 and released in January 1949, an original screenplay written collaboratively by Royal K. Cole, Basil Dickey, William Lively and Sol Shor as a crime story with elements of "the mysterious Orient" incorporated in the plot.

Nila (Carol Forman), an Abistahnian criminal, and Spade Gordon (Roy Barcroft), an American gangster, conspire to form a super-mob dubbed Underworld, Incorporated, funded by the treasure of Kurigal I of Abistahn, instructions for the location of which are contained in hieroglyphics written on two golden statues in the shape of hands, found in Kurigal's tomb.

When the professor in charge of the tomb's dig disappears under mysterious circumstances while translating the writing on one of the hands back at his American office, a team of special government agents led by David Worth (Kirk Alyn) and his aide Steve Evans, assisted by the professor's aide Laura Keith (Rosemary La Planche), set out to find the professor and the now-missing hands.

Federal Agents vs. Underworld, Inc. was budgeted at $156,120 although the final negative cost was $155,807 (a $313, or 0.2%, under spend).

[1] Federal Agents vs. Underworld, Inc. was one of twenty-six Republic serials re-released as a film on television in 1966.