Federico Spinola (1571–1603) was an Italian naval commander in Spanish Habsburg service during the Dutch Revolt.

Spinola was born in Genoa in 1571 and studied at the University of Salamanca in preparation for an intended ecclesiastical career.

In 1598, he travelled to Madrid with a proposal to build up a fleet of galleys in Flanders that could be used to launch an invasion of England.

[1] Approval was granted, and a squadron of six galleys was placed under his command, which he sailed to Sluis in 1599, establishing his base of operations there.

On 26 May the following year, Spinola died in the Battle of Sluis (1603), bringing to an end his experiment in adopting Mediterranean naval warfare to northern waters.