Felipe Segundo Guzmán (17 January 1879 – 16 June 1932) was a Bolivian politician who served as the 30th president of Bolivia on an interim basis from 1925 to 1926.

A university professor and scholar, he championed the teaching of Spanish to native Bolivians, and called for a further incorporation into national life of the great mass of "Indians" which comprised the country's majority.

Congress, in turn, chose the head of the Senate, Guzmán, who was sworn in on September 3, 1925, and given the task of calling fresh elections within a year.

This done, and with the triumph at the polls of the government endorsed candidate Hernando Siles, Guzmán left office in August 1926 and returned to relative obscurity.

Felipe Segundo Guzmán died in la Paz in June 1932, at the age of 53.