Once in Alaska, Pedro panned for gold in the Fortymile, the Piledriver Slough near present-day Salcha, and various other waterways, including the "Lost Creek" in which Pedro and his partner Tom Gilmore claimed to have found a sizable amount of gold in 1898, but were forced to abandon due to food shortage.

On August 26, 1901, prospector E. T. Barnette and Captain Charles W. Adams ran the 150-foot (46 m) steamer Lavelle Young aground 8 miles (13 km) up the Chena River which they mistakenly believed to be a distributary which would allow them to detour upstream from the unnavigable Bates Rapids to their intended destination in Tanacross.

The crew quickly built two log cabins and a series of tents, establishing a trading post named Chena City.

Pedro and Gilmore, still in search of the Lost Creek, were perched on a nearby slope and had seen the plumes of smoke from the departing steam-boat.

Felix Pedro died July 22, 1910, at age 52 at St. Joseph's Hospital in Fairbanks, reportedly of a heart attack.

On October 12, 1972, Pedro's body was found, exhumed, and moved by Cortelloni Amato to Italy where an autopsy was performed, and the hair samples reportedly supported the conclusion that Pedroni was murdered.