[3][4] Born in Pest,[1] Hungary to French parents,[2] Darier studied with Louis-Antoine Ranvier (1835–1922) at the Collège de France.

The other diseases were a follicular keratosis (Darier-White syndrome), dermatofibrosarcoma (Darier-Ferrand disease), erythema annularis, subcutaneous sarcoidosis (Darier-Roussy sarcoid), and a sign, Darier's sign observed in mastocytosis.

[5] He was one of the "big five" of the Paris School of Dermatology, along with Ernest Henri Besnier (1831–1909), Louis-Anne-Jean Brocq (1856–1928), Raymond Sabouraud (1864–1938) and Jean Alfred Fournier (1832–1915).

Darier wrote the dermatology textbook Précis de dermatologie, which was published in 1909 and translated into Spanish, German and English.

[2] He was also the editor of the dermatological encyclopedia Nouvelle Pratique Dermatologique, which was published in eight volumes, beginning in 1936.