He pioneered the field of Magnetic Resonance Imaging-guided interventions and introduced of a variety of new medical procedures based on novel combinations of imaging and therapy delivery.

Jolesz became director of the Division of Magnetic Resonance Imaging at The Brigham and Women's Hospital in 1988, and in 1989, associate professor of radiology at Harvard Medical School.

Where they did not previously exist, Jolesz spearheaded the development and implementation of highly novel approaches to image processing and analysis, visualization, and navigation techniques for improving the diagnosis and treatment of neurologic and oncologic diseases.

These techniques include Fast Spin Echo (FSE), which can be used for all weightings in all body regions and parts, permits decreased scan times, and allows for either higher resolution or better signal to noise ratios.

One particularly promising application for MRgFUS envisioned by Jolesz is its use to open the blood-brain barrier, allowing drugs to be delivered to the brain and neural system to provide otherwise-impossible treatments.

Such a system would expand the ability of the surgeon to deliver highly targeted therapy to a patient in a less invasive manner, while better monitoring the efficacy of the treatment during the procedure using intraoperative imaging.

Jolesz and his NCIGT colleagues realized this vision with the completed installation in 2011 of the Advanced Multimodality Image Guided Operating suite (AMIGO) at BWH.

[5] Published in 2014, the book "Intraoperative Imaging and Image-Guided Therapy," edited by Jolesz demonstrates his zeal for sharing the latest ideas and techniques, encouraging others to join in the quest for progress in biomedical research that translates to new, improved clinical care of patients.