The Fiesole Altarpiece is a painting by the Italian early Renaissance master Fra Angelico, executed around 1424–1425.

The saints Thomas Aquinas, Barnabas, Dominic and Peter of Verona are at the sides: these were three saints of the Dominican Order (the same owning the convent) and the namesake of Barnaba degli Agli, a Florentine man who had donated 6,000 florins for the convent's restoration and enlargement.

The naked Child is shown while grasping two flowers: a white rose, symbol of purity, and a red one, a forecast of his future passion connected with the Eucharist: the panel was in fact painted for the church's high altar, where the celebration of this sacrament occurs.

The work had a predella, now at the National Gallery, London and portraying Adoration of Saints, Prophets and Members of the Dominican Order.

The side pillars were decorated by ten small panels with saints and blessed, four of which are known today: two are at the Musée Condé of Chantilly and two in private collections.