Filippo Calandrini (1403 – 18 July 1476) was an Italian Roman Catholic cardinal and half-brother of Pope Nicholas V. He was born in 1403 in Genoese Sarzana (now in the region of Liguria), a town located in ancient Lunigiana, a key border region which Tuscans and Ligurians long struggled to control.
His father was Tommaso Calandrini from a family originating from Lucca, his mother was the latter's second wife Andreola Tomeo dei Bosi, the widow of Bartolomeo Parentucelli, whose son Tommaso Parentucelli became pope Nicholas V. from 1447 until 1455.
In 1448, he was named cardinal Priest of Santa Susanna, his former titular church.
Cardinal Calandrini also had Pope Pius issue a brief on 7 April 1461 (vainly) prohibiting removal of Roman remains from Luni.
Filippo died at Bagnoregio, at the age of 73 and was buried at San Lorenzo in Lucina, Rome.