Filthbreed is an adventure horror game in which the player explores the rumored headquarters of a cult in Michigan as a police officer investigating the disappearance of homeless people in the area.

The game features a rudimentary weapons system with a gun to defend against attacks from human-insect hybrid monsters as they explore the area.

[3] Players are able to investigate their surroundings and discover notes from the prime suspect, a truck driver named Louie Burton, to provide more insight into the history of the disappearances.

Henschke highlighted the use of the weapon system to create "an extra layer of tension" as "simple but effective", although critiquing the game's short play time and limited content, being "only about ten minutes long" to complete.

[2] Catherine Brinegar of RE:BIND praised the game as a "deeply unnerving experience", highlighting its "masterclass of horror sound design" and "dingy rendering of bleak rooms" to "push in a direction that heightens the tension and atmosphere with the slight abstraction of what you're seeing.