The Fiocruz Genome Comparison Project is a collaborative effort involving Brazil's Oswaldo Cruz Institute and IBM's World Community Grid, designed to produce a database comparing the genes from many genomes with each other using SSEARCH.
This, along with the likely humanitarian benefits of the research, has led the World Community Grid (a volunteer computing grid that uses idle computer clock time) to run the Fiocruz project.
Additionally, many proteins composed of several structural and/or functional domains are overlooked by automated systems.
The Genome Comparison Project performs a complete pairwise comparison between all predicted protein sequences, obtaining indices used (together with standardized Gene Ontology[2]) as a reference repository for the annotator community.
This program mathematically finds best local alignment between sequence pairs,[3] and is a freely available implementation of the Smith–Waterman algorithm.