It was previously known as the American Indian Cultural Center and Museum.

[5][6] The mission of First Americans Museum is, "To serve as a dynamic center promoting awareness and educating the broader public about the unique cultures, diversity, history, contributions, and resilience of the First American Nations in Oklahoma today.

"[7] The FAM's executive director is James Pepper Henry (Kaw/Muscogee).

[4] Deputy director is Shoshana Wasserman (Thlopthlocco Muscogee).

[8] Loretta Barrett Oden (Potawatomi) is a culinary architect in the museum's on-site Thirty Nine Restaurant.