13 Waterhouse Street First Church of Christ, Scientist is an historic redbrick 6-story domed Christian Science church building located at 13 Waterhouse Street, in Cambridge, Massachusetts.

It was designed in 1917 by church member Giles M. Smith of the noted Boston architectural firm of Bigelow and Wadsworth (later Bigelow, Wadsworth, Hubbard and Smith), who patterned it after Thomas Jefferson's The Rotunda at the University of Virginia and the Pantheon in Rome.

Guastavino used its patented tile arch system consisting of Akoustolith, a porous ceramic material resembling stone, on the interior, with limestone on the exterior.

In 1933 copper flashing was added to the exterior of the dome in order correct a leakage problem.

The first services in the completed building were held on April 30, 1930, and after becoming debt free, it was dedicated on May 23, 1937.