First National Bank of Seaford is a historic bank building located at Seaford, Sussex County, Delaware, United States.

It was built in 1868, and is a two-story, five-bay, rectangular brick structure in the Italianate style.

It has a hipped roof with dormers and a two-story, frame addition.

It is the oldest standing bank building in Seaford and has been converted to apartments.

This article about a property in Delaware on the National Register of Historic Places is a stub.