First National of Nebraska, Inc. is an interstate bank holding company based in Omaha, Nebraska, and is the parent company of First National Bank of Omaha.

It brought in additional investors, including Edward Creighton, who served as president.

Attached to a 420-room hotel and a 550-stall parking garage, it became one of the most modern buildings in the region, providing economic development in downtown Omaha.

[7] In 2010, the bank sold a 51% interest in its merchant acquiring business to TSYS for $150.5 million.

[11] In 2018, the bank ended its credit card affinity program with the National Rifle Association of America (NRA) due to customer complaints after the Parkland high school shooting.