The neighborhood is home to several other churches, including the Trinity Episcopal Cathedral, the First Unitarian Church of San Jose, Our Lady of La Vang Parish, and the Cathedral Basilica of St. Joseph.
John W. Douglas, a young Presbyterian minister, arrived at Monterey Bay, California via steamship.
A new church building, located at 48 N. 3rd Street, was completed and dedicated in April 1908.
On June 30, 2019, the First Presbyterian Church of San Jose held its last Sunday service, which was attended by members, friends and guest musicians.
In 1944, a committee of elders laid the foundations of the Foothill Presbyterian Church.